Investigation of Cell growth signaling via mTOR using RNAi Technology

• Applicant: Privatdozentin Dr. Claudia Bürger
• Subject Area: Cell Biology
• Term: from 2005 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5450500

• Final Report Year: 2008

Final Report Abstract

In summary this work contributed essentially to the growing knowledge in the field of growth signaling, which is reflected by a huge interest in our work, presentations and publications by the scientific community. I could identify a crucial mechanism of mTOR regulation through compartment specific localization of Rheb and was able to describe a new signaling component, namely Epac2 that activates Rheb by charging it with GTP.

Publications

• (2006) Localization of Rheb to the endomembrane is critical for its signaling function. Biochem Biophys Res Commun. 2006 Jun 9;344(3):869-80
  Claudia Buerger, Ben DeVries and Vuk Stambolic