Coordination of endoplasmic reticulum-associated fidelity machines (B02)

• Subject Area: Biochemistry ; General Genetics and Functional Genome Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. While ER-associated RNA silencing (ERAS) reduces ER overload, ER-associated protein degradation (ERAD) prevents the accumulation of misfolded proteins in the ER lumen. Notably, ERAS and ERAD play complementary roles in ER protein fidelity to maintain ER homeostasis and tissue integrity. The central goal of the proposed research is to understand the spatiotemporal coordination and physiological consequences of mRNA and protein turnover under ER stress conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Thorsten Hoppe