Chronic stress-associated alterations of translation fidelity (B04)

• Subject Area: Biochemistry ; Bioinformatics and Theoretical Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

This project addresses the long-standing question in the field as to whether the concentrations of the translation components change with chronic exposure to oxidative stress, and how this influences translation fidelity and proteome composition. For this, we will obtain a full quantitative inventory of the translation machinery (Ignatova group) and combine that with statistical modeling (Tresch group) using cell model systems and different murine tissues.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Heads: Professorin Dr. Zoya Ignatova; Professor Dr. Achim Tresch