Predicting the impact of biosynthetic fidelity on protein folding (B05)

• Subject Area: Cell Biology ; Bioinformatics and Theoretical Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

The declining fidelity of mRNA production and translation contributes to protein misfolding and aggregation. To systematically address how the fidelity of mRNA and protein synthesis contribute to protein (mis)folding, we will combine recent advances in proteome-scale protein structure analysis with computational modelling. This approach will enhance the mechanistic interpretation of the data and it will identify proteins that are particularly vulnerable to a declining fidelity of biosynthesis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• International Connection: Switzerland
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Andreas Beyer; Professorin Dr. Paola Picotti