Defining the interplay between RNA and protein toxicity in C9orf72-related amyotrophic lateral sclerosis (ALS) (B06)

• Subject Area: Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

Expanded hexanucleotide (GGGGCC)n repeats in the C9orf72 gene account for 30% of familial ALS cases. These repeats result in the accumulation of abnormal nuclear foci and cytosolic stress granules (SGs) in motor neurons. In this project, we will conduct a comprehensive system-wide analysis to define converging alterations in interconnected RNA and protein fidelity processes induced by mutant C9orf72-associated nuclear RNA foci and cytosolic SGs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. David Vilchez