Charakterisierung der MBL (mannose binding lectin)-abhängigen Aktivierungen des Komplementsystems bei der myokardialen Ischämie- und Reperfusion (MI/R), der Rolle von C1q bei MI/R sowie Charakterisierung der Mechanismen MBL-abhängiger myokardialer Schädigung nach MI/R

• Antragsteller: Privatdozent Dr. Marc Nicolai Busche
• Fachliche Zuordnung: Allgemein- und Viszeralchirurgie ; Orthopädie, Unfallchirurgie, rekonstruktive Chirurgie
• Förderung: Förderung von 2005 bis 2007
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5450978

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol. 2005;175:541- 6
  Walsh MC, Bourcier T, Takahashi K, Shi L, Busche MN, Rother RP, Solomon SD, Ezekowitz RA, Stahl GL
  
• Increased susceptibility to myocardial ischemia and reperfusion injury in type I diabetes mellitus is mannose-binding lectin dependent. Experimental Biology (FASEB) 2007, April 28 - May 2; Washington, DC, USA
  Busche MN, Walsh MC, Stahl GL
  
• Increased susceptibility to myocardial ischemia and reperfusion injury in type I diabetes mellitus is mannose-binding lectin dependent. Experimental Biology (FASEB) 2007, April 28; Washington, DC, USA
  
  
• Mannose-binding lectin plays a critical role in diabetic cardiomyopathy, hypertrophic remodeling and myocardial ischemia and reperfusion injury. 11th European Meeting on Complement in Human Diseases 2007, September 9; Cardiff, Wales, GB
  
  
• Mannose-binding lectin plays a critical role in diabetic cardiomyopathy, hypertrophic remodeling and myocardial ischemia and reperfusion injury. 11th European Meeting on Complement in Human Diseases 2007, September 9; Cardiff, Wales, GB
  Busche MN, Walsh MC, McMullen ME, Guikema BJ, Stahl GL
  
• Mannose-binding lectin plays a critical role in diabetic cardiomyopathy, hypertrophic remodeling and myocardial ischemia and reperfusion injury. Mol Immunol. 2007 Sept;44:3912
  Busche MN, Walsh MC, McMullen ME, Guikema BJ, Stahl GL
  
• Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin. Mol Immunol. 2007 Sept;44:3936
  Busche MN. Walsh MC, Guikema BJ, McMullen ME, Stahl GL
  
• Myocardial ischemia and reperfusion injury is dependent on both IgM and mannosebinding lectin. 11th European Meeting on Complement in Human Diseases 2007, September 9; Cardiff, Wales, GB
  Busche MN, Walsh MC, Guikema BJ, McMullen ME, Takahashi K, Stahl GL
  
• Role of the mouse complement components C5 and C3a in a model of myocardial ischemia and reperfusion injury. Experimental Biology (FASEB) 2007, April 28 - May 2; Washington, DC, USA
  Busche MN, Walsh MC, Stahl GL
  
• Role of the mouse complement components C5 and C3a in a model of myocardial ischemia and reperfusion injury. Experimental Biology (FASEB) 2007, April 28; Washington, DC, USA
  
  
• Mannose-binding lectin plays a critical role in myocardial ischemia and reperfusion injury in a mouse model of diabetes. Diabetologia. 2008;51:1544-1551
  Busche MN, Walsh MC, McMullen ME, Guikema BJ, Stahl GL