Project Details
Projekt
Metabolic signaling as a safeguard of translational fidelity (B08)
Subject Area
Cell Biology
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345
Protein biosynthesis is subject to an interplay between resource availability and demands set by growth signals. Translation is directly affected by the metabolic state of the cell, including levels of ATP and amino acids as well as elaborate modification of (t)RNA species. In this project, we will determine how pathways such as mTOR and ERK, which regulate translation in response to growth signals and the metabolic state, modulate translational fidelity. To achieve this, we combine pathway activity scoring with detailed experimentation to uncover mechanistic links between metabolic challenges, signaling and the translational process.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1678:
Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
Applicant Institution
Universität zu Köln
Project Heads
Professorin Dr. Zoya Ignatova; Dr. Matthias Weith
