Single Molecule Based Ultra High Density Memory
Final Report Abstract
Important scientific and technological advances have been achieved during the funding period. One of the main technical achievements was the establishment of an advanced lab in un-easy surrounding conditions by the Palestinian partner (M. Sowwan). He and his group were trained on AFM techniques at and by the Israeli’s partner lab (D. Porath, Hebrew University). Meanwhile the lab has been fully established and it is able to work on its own. On the scientific side, the main achievements can be summarized as: (i) genetical engineering of SP1-proteins to selectively bind nanoparticles near the inner pore (Au or SiO2), (ii) assembling of 1D-arrays of SP1/NP hybrids and 2D-arrays of the SP1-protein in solution and deposition on surface, (iii) electrical and morphological characterizations of SP1-protein rings, SP1-NP hybrids, and tubes made of the hybrids and 2D-arrays, performed using Electrostatic Force Microscopy (EFM), (iv) on the theoretical side, the German group successfully developed efficient methodologies to treat charge transport in dynamically disordered biological systems. These joint efforts created the tools necessary to go one step further and address information processing and control in self-organized SP1-NP networks. This issue turned out to be considerably more challenging and could not be fully studied during the granted period. Nevertheless the current proposal strongly helped to establish a collaborative network among the three participants.
Publications
- SP1 Protein Based Nanostructures and Arrays, Nano Letters 8, 473 (2008)
Medalsy I, Dgany O, Sowwan M, Cohen H, Yukashevska A, Wolf SG, Wolf A, Koster A, Almog A, Marton I, Pouny Y, Altman A, Shoseyov O and Porath D
- Charge transport through biomolecular wires in a solvent: Bridging molecular dynamics and model Hamiltonian approaches, Phys. Rev. Lett., 102, 208102 (2009)
R. Gutierrez, R. Caetano, P. B. Woiczikowski , T. Kubar , M. Elstner, and G. Cuniberti
- Combined DFT and Landauer approach for hole transfer in DNA along classical MD trajectories, J. Chem. Phys. 130, 215104, (2009)
P. Woiczikowski , T. Kubar, R. Gutierrez, R. Caetano, G. Cuniberti , and M. Elstner
- Float and compress: honeycomb-like array of a highly stable protein scaffold. Langmuir 25, 5226 (2009)
Heyman A, Medalsy I, Dgany O, Porath D, Markovich G, Shoseyov O
- Protein scaffold engineering towards tunable surface attachment, Angew Chem Int Ed Engl. 48, 9290 (2009)
A. Heyman, I. Medalsy, Or O Bet, O. Dgany, M. Gottlieb, D. Porath, O. Shoseyov
- STM spectroscopy of single DNA molecules, ACS Nano, 3 1651 (2009)
A. Ryndyk, E. Shapir, D. Porath, A. Calzolari, R. Di Felice, and G. Cuniberti
- Logic implementations using a single nanoparticle-protein hybrid, Nature Nanotechnology 5, 451 (2010)
I. Medalsy, M. Klein, A. Heyman, O. Shoseyov, F. Remacle, R.D. Levine, D. Porath
- Structural fluctuations and quantum transport through DNA molecular wires: a combined molecular dynamics and model Hamiltonian approach, New J. f Phys. 12, 023022 (2010)
R. Gutierrez, R. Caetano, P. B. Woiczikowski, T. Kubar, M. Elstner, and G. Cuniberti
- SP1 Protein-Gold Nanoparticle Hybrids as Building Blocks for Nanofabrication of One-Dimensional Systems. In: From Bionanotechnology II: Global Prospects Editor: Reisner DE. (2011) CRC Press
I. Medalsy, O. Dgany, A. Heyman, O. Shoseyov, M. Sowwan, and D. Porath
- Wiring of Redox Enzymes on Three Dimensional Self-Assembled Molecular Scaffold. Langmuir 27, 12606 (2011)
M. Frasconi, A. Heyman, I. Medalsy, D. Porath, F. Mazzei, O. Shoseyov
