Ontogeny of CL- homeostasis in spherical bushy cells (SBC) on the anteroventral cochlear nucleus (AVCN): impact on GABAergic and glycinergic neurotransmission

• Antragsteller: Professor Dr. Ivan Milenkovic
• Fachliche Zuordnung: Kognitive, systemische und Verhaltensneurobiologie
• Förderung: Förderung von 2005 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5452597

• Erstellungsjahr: 2013

Zusammenfassung der Projektergebnisse

Sound source localization is in vertebrates accomplished by the processing of auditory cues, encoded in the activities of excitatory and inhibitory neurons. While the excitation with its origin in the cochlear hair cells is conveyed by glutamate throughout the auditory system, the non-primary, acoustically-evoked inhibition is in mammals and birds mediated by glycine and γ-Aminobutiric acid (GABA). In mammals, GABAergic transmission appears prominent at some brainstem neurons in early postnatal life, but during development the predominant transmitter phenotype changes to glycine. The latter provides strong inhibition, endowed with fast kinetics, and capable of increasing the temporal sensitivity of respective brainstem neurons. Yet, in investigated brainstem nuclei of the rat, mice and gerbil, GABA and/or glycine act depolarizing early after birth, due to prolonged postnatal maturation of the chloride homeostasis system. The time course of the shift from depolarizing to hyperpolarizing inhibitory transmission is staggered in time (from

Projektbezogene Publikationen (Auswahl)

• (2007). Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus. J Neurophysiol, 98:1634-1644
  Milenkovic I., Witte M., Turecek R., Heinrich M., Reinert T., Rübsamen R.
  
• (2008). Glycinemediated changes of onset reliability at a mammalian central synapse. Neuroscience, 157:437-445
  Kopp-Scheinpflug C., Dehmel S., Tolnai S., Dietz B., Milenkovic I., Rübsamen R.
  
• (2008). Synaptic transmission and short term plasticity at the calyx of Held synapse revealed by multielectrode array recordings. J Neurosci Methods, 174:227-236
  Haustein M., Reinert T., Warnatsch A., Englitz B., Dietz B., Robitzki A., Rübsamen R., Milenkovic I.
  
• (2009). P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus. J Neurophysiol, 102:1821-1833
  Milenkovic I., Rinke I., Witte M., Dietz B., Rübsamen R.
  
• (2011). Development of the chloride homeostasis in the auditory brainstem. Physiol Res, 60 Suppl 1:S15-27
  Milenkovic I., Rübsamen R.