Structure-function analyses of NAC transcription factor proteoforms (A01)

• Subject Area: Plant Genetics and Genomics ; Biochemistry ; Plant Biochemistry and Biophysics ; Bioinformatics and Theoretical Biology ; Biophysics ; Evolution and Systematics of Plants and Fungi ; Plant Physiology ; Structural Biology ; Plant Cell and Developmental Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

A01 investigates NAC transcription factors and aims to explore functional diversification between proteoforms, particularly in less structured C-terminal regions. By combining plant molecular biology and structural biochemistry, the project assesses NAC proteoforms for DNA sequence affinity, specificity, and protein interactions. NMR studies are crucial for understanding structure-function relationships. The project specifically examines NACs related to secondary cell wall synthesis and stress responses, revealing differences in target gene activation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Jochen Balbach; Dr. Carolin Delker