Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis (A05)

• Subject Area: Biochemistry ; Plant Biochemistry and Biophysics ; Bioinformatics and Theoretical Biology ; Biophysics ; Evolution and Systematics of Plants and Fungi ; Plant Genetics and Genomics ; Plant Physiology ; Structural Biology ; Plant Cell and Developmental Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

The project focuses on proteins involved in the biogenesis of miRNAs, addressing protein-nucleic acid interactions. It explores the dicing complex, which processes primary miRNAs into mature forms, analyzing proteoforms for their impact on miRNA production, binding behaviors, and structural changes affecting processing activity. Rational protein design, utilizing observed SNPs and computational methods, aims to create modified proteins. This project brings a structural approach to protein design, expected to be a crucial focus in future funding periods.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Sascha Laubinger; Professorin Dr. Clara Schoeder