Allelic variation in the control of calcium-dependent protein kinase activity and function in plant-environment interactions (B02)

• Subject Area: Plant Physiology ; Biochemistry ; Plant Biochemistry and Biophysics ; Plant Genetics and Genomics ; Structural Biology ; Plant Cell and Developmental Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

In the project members of a family of calcium sensors with kinase activity will be investigated. These CDPKs are involved in the regulation of environmental stress responses as well as developmental processes. Three CDPK family members with nsSNPs that are proposed to either affect kinase activity, enzyme localization, or interaction with substrates were selected. Specifically, single and/or clustered nsSNPs may target regulatory sites within the protein influencing enzyme (auto-)phosphorylation or calcium dependency, which functionally translates into altered stress signaling or confer crosstalk between different pathways.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professorin Dr. Tina Romeis; Professorin Dr. Andrea Sinz