Modelling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era (D01)

• Subject Area: Plant Genetics and Genomics ; Plant Biochemistry and Biophysics ; Bioinformatics and Theoretical Biology ; Structural Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

D01 aims to computationally model Arabidopsis proteoforms on a proteome-wide scale. Given the limited protein structures for Arabidopsis, the project will connect genomic information from SNPstar with protein structure and function predictions. This initiative will establish a crucial structural bioinformatics resource, creating a comprehensive atlas of nsSNP effects in Arabidopsis. This resource will facilitate investigations into the links between genetic variation and phenotypic outcomes, benefiting multiple CRC projects. Additionally, it lays the foundation for enhancing plant proteins in subsequent funding periods.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Panagiotis L. Kastritis; Dr. Georg Künze