Characterization of repolarization in ventricular myocardium with a new approach to the solution of the inverse problem of electrocardiography
Final Report Abstract
The non-invasive reconstruction of cardiac activity can be a very useful tool for cardiologists enabling them to improve the quality of cardiac diagnostics. Three major approaches are considered in this work. The model-based method consists in the optimization of an electrophysiological cardiac model until the measured a simulated ECGs are similar. The optimized parameters include the excitation conduction velocity in different tissues, the dispersion of action potential duration as well as the site and size of infarction. The second method is the solution of the inverse problem of electrocardiography, which implies the computation of the cardiac sources distribution from a body surface potential map. All major techniques to solve the ill-posed problem have been implemented and tested with clinical data (Tikhonov 0 order, Tikhonov 2nd order, Tikhonov-Greensite, GMRes). The third method is based on using an a priori estimate to solve the inverse problem (MAP-regularization). The statistical basis is constructed from many simulations with various parameters. The inverse problem is solved for several patients, the solution results and their interpretation are demonstrated.
