Bioinspired nanocomposites for early detection of complications in gastrointestinal surgery (B12*)

• Subject Area: Cell Biology ; General and Visceral Surgery ; Biomaterials ; Gastroenterology ; Measurement Systems
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 286471992

The aim of this interdisciplinary project is to develop an in vivo implant to detect specific biomarkers of anastomotic leakage after partial intestinal removal. The implant is based on intracorporally applied, magnetically labeled, synthetic receptors and communicates by means of a readout system based on magnetoelectric sensors. The project includes the identification of accurate and reliable biomarkers and the realization of an implant containing appropriate nanoparticles with a concentration-dependent magnetic signal strength. The realization of a contactless readout system and the validation of the approach in a cell assay and in small animal models complete the project.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1261: Magnetoelectric Sensors: From Composite Materials to Biomagnetic Diagnostics
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Heads: Professorin Dr.-Ing. Zeynep Altintas; Professorin Dr. Martina Gerken; Dr. Jan-Paul Gundlach