Context effects on threat processing in dependence of testosterone levels (A02)

• Subject Area: Biological Psychiatry ; Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073

The project aims to analyze the modulating function of provocative context under different testosterone levels on threat sensitivity in healthy controls as well as patient groups. Additionally, we will determine the influence of endogenous hormone variations on NVS in high versus low aggressive patients in a large group of patients. With this sample, we will try to identify multidimensional biosignatures based on hormonal levels in combination with fMRI measures of amygdala and amygdala-prefrontal connectivity, NVS measures by questionnaires, aggression measures and psychopathological data.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 379: Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professorin Dr. Katja Bertsch, Ph.D.; Professorin Dr. Ute Habel; Professorin Dr. Sabine C. Herpertz