Modulation of aggression by acute threat (A03)

• Subject Area: Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073

The main translational research question is if and how aggressive responses are modulated by threat, and which neurofunctional and neurochemical patterns underlie these responses during safe and threat conditions. MR spectroscopy will be used in patients to assess glutamate and GABA levels. In a further translational approach, the least and the most aggressive/impulsive recombinant inbred mouse lines will be tested with animal MR spectroscopy at 9.4T to determine the relationship between glutamate, GABA, impulsivity, and aggression in these mouse lines as well as in comparable brain regions assessing neurofunctional and neurochemical patterns.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 379: Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professorin Dr. Gabriele Ende; Professor Dr. Christian Schmahl