Gene-environment interactions and the role of impulsivity in responding to acute threats: early-life stress and escalated aggression in recombinant inbred mouse strains (C01)

• Subject Area: Biological Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073

The project will investigate the effects of early life stress on aggression in response to threat and hyperactivity as well as social decision-making in 32 BXD mouse strains, the progenitor strains (C057Bl/6J and DBA/2J), and the F1 BXD cross. The project aims to identify the quantitative trait loci (QTL) and putative candidate genes contained within the QTL and associate them with specific behavioral responses of stressed and unstressed mice.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 379: Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Dr. Aet O' Leary, Ph.D.; Professor Dr. David Slattery, Ph.D.