Novel paradigms in the regulation of mitochondrial integrated stress responses (B13*)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Over the last few years, it became clear that one specific pathway has been activated in response to perturbation in OXPHOS activity, preceding other adaptive changes in mitochondrial biogenesis or antioxidant defence, namely the mitochondrial integrated stress response (mitoISR). We propose to further dissect this stress response by specifically investigating the regulation and consequences of acute to chronic mitoISR switch and dissecting the role of mitoISR in the regulation of postmitotic differentiation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Aleksandra Trifunovic