The link between mitochondrial ultrastructure and innate immune response upon fumarate hydratase loss (B14*)

• Subject Area: Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

In this project we will shed light on the molecular connection between the accumulation of the metabolite fumarate caused by FH loss and the changes in mitochondrial ultrastructure and the ensuing release of mtDNA, as well as the effects of the resulting interferon response on renal cell carcinoma. We will address the main open questions in three working packages. First, we will elucidate the molecular link between accumulated fumarate and mitochondrial derived vesicle (MDV) formation. Then, we will identify molecular players of MDV formation and the interferon response and finally we will investigate the (patho)physiological consequences of the triggered innate immune response in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Christian Frezza; Dr. Dèsirée Schatton