SFB 1739:  Soft tissue-alveolar bone crosstalk - Impact of systemic diseases on mechanisms of periodontal remodelling

• Subject Area: Medicine
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 546544928

No abstract available

• DFG Programme: Collaborative Research Centres
• International Connection: Netherlands

Current projects

• MGK - Integrated Research Training Group: ‘Periodontal remodelling in systemic diseases’ (Project Heads Knaup, Isabel ;  Noels, Ph.D., Heidi ;  Wolf, Michael )
• PR01 - Alveolar bone remodelling amelioration using Nuclear factor erythroid 2-related factor 2 (Nrf2) in osteonecrosis of the jaw (Project Heads Bock, Anna ;  Pufe, Thomas )
• PR02 - Modelling and modulation of periodontal remodelling under systemic disease conditions using a locally injectable hydrogel system (Project Heads Craveiro, Rogerio Bastos ;  Shi, Ph.D., Yang )
• PR03 - The synergistic impact of obesity and type 2 diabetes mellitus on intraoral tissue remodelling (Project Heads Hölzle, Frank ;  van der Vorst, Emiel )
• PR04 - Dissecting the role of the periodontal-immune axis in mechanically induced tissue remodelling using an advanced dynamic 3D in vitro model (Project Heads Fischer, Horst ;  Jansen, Ph.D., Jitske )
• PR05 - Dissecting systemic disease impact on periodontal remodelling: functional comparison of iPSC-derived and native PDLSCs (Project Heads Niederau, Christian ;  Schurgers, Ph.D., Leon )
• S01 - Advancement and standardisation of animal model analyses (Project Heads Craveiro, Rogerio Bastos ;  Tolba, René H. )
• S02 - Imaging the dental microenvironment and its systemic crosstalk (Project Heads Boor, Peter ;  Mottaghy, Felix ;  Rizk, Marta )
• S03 - Mass-spectrometric approaches to identify, quantify and localise novel crosstalk mediators of pathological processes underlying periodontal remodelling (Project Heads Jankowski, Joachim ;  Jankowski, Vera )
• SD01 - Analysing the effect of bone disease on periodontal remodelling (Project Heads Apel, Christian ;  Modabber, Ali ;  Rosado Balmayor, Ph.D., Elizabeth )
• SD02 - Cellular and oral inflammatory processes of periodontal remodelling in chronic kidney disease (Project Heads Conrads, Georg ;  Kuppe, Christoph )
• SD03 - Characterisation of recently identified mediators directing mechanisms of periodontal remodelling in chronic kidney disease (Project Heads Jankowski, Joachim ;  Wolf, Michael )
• SD04 - Impact of systemic low-grade complement activation on alveolar soft and hard tissue in patients with cardio-vascular disease (Project Heads Kern, Jaana-Sophia ;  Marx-Schütt, Katharina )
• SD05 - Dissecting the mechanisms linking chronic kidney disease, cardiovascular disease, and periodontal remodelling (Project Heads Knaup, Isabel ;  Kramann, Rafael )
• SD06 - Innate trained immunity in the pathophysiological crosstalk of hyperlipidemic metabolic disturbances and periodontitis (Project Heads Noels, Ph.D., Heidi ;  Schulze-Späte, Ulrike )
• SD07 - Effects of heart failure on periodontal remodelling (Project Heads Marx, Nikolaus Albert Helmut ;  Rizk, Marta )
• SD08 - JAK2V617F-driven inflammation and bone remodelling in myeloproliferative neoplasms: exploring the link to periodontal disease for biomarker discovery and targeted therapy (Project Heads Schneider-Kramann, Rebekka ;  Wolf, Michael )
• SD09 - Elucidating circuits of periodontal-liver crosstalk in metabolic liver disease (Project Heads Schneider, Ph.D., Kai Markus ;  Wolfart, Stefan )
• Z01 - Central tasks of the SFB1739 (Project Head Wolf, Michael )

• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Participating University: Universitätsklinikum Jena ; Zentrum für Zahn-, Mund- und Kieferheilkunde; Poliklinik für Konservierende Zahnheilkunde und Parodontologie; Universitätsklinikum Carl Gustav Carus Dresden; Technischen Universität Dresden; Professur für Innere Medizin und Kardiologie
• Participating Institution: University of Maastricht ; Cardiovascular Research Institute ; Maastricht (CARIM) ; Department of Biochemistry
• Spokesperson: Professor Dr. Michael Wolf