Systematic analysis of ER-shaping Reticulon and REEP proteins (P01)

• Subject Area: Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 511488495

To understand how the complex architecture of the ER is generated, we propose to systematically analyze the major ER membrane-shaping proteins of the Reticulon and REEP families. We will first characterize their molecular environments, second determine their precise localization in cells and third investigate their functions by a targeted degradation approach. This work will help to elucidate how different ER subdomains are established and enable the various functions of the organelle.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1638: Cellular membrane remodelling – how changing form creates function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Dr. Anne-Lore Schlaitz