Mechanisms of Endoplasmic Reticulum morphogenesis (P02)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 511488495

This project investigates the molecular mechanisms by which the morphology of the endoplasmic reticulum (ER) is generated and dynamically remodelled. Specifically, it will test the hypothesis that reversible clustering of reticulon homology domain proteins controls ER shape and volume. Furthermore, it will explore how complex ER structures, such as stacks and whorls, are formed. Through these studies, this project aims to advance our understanding of ER morphogenesis and, ultimately, enable new means to manipulate ER architecture for therapeutic benefit.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1638: Cellular membrane remodelling – how changing form creates function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Sebastian Schuck