Membrane remodelling during the mitochondrial unfolded protein response (P09)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 511488495

Mitochondrial defects induce a nuclear transcriptional response (mitochondrial unfolded protein response (mtUPR)), leading to an increase in mitochondrial chaperones and proteases, but also resulting in increased levels and remodelling of the mitochondrial signature lipid cardiolipin (CL) and transcriptional changes in lipid biogenesis enzymes. We hypothesize that mitochondrial stress induces global lipid changes and membrane remodelling. We aim to investigate how CL remodelling protects mitochondrial integrity and how mtUPR affects global lipid homeostasis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1638: Cellular membrane remodelling – how changing form creates function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Friederike-Nora Vögtle