SFB 518:  Inflammation, Regeneration and Transformation in the Pancreas

• Subject Area: Medicine ; Biology
• Term: from 1998 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5482728

Within the topic of inflammation and regeneration, inflammatory processes of the exocrine and endocrine pancreas are examined. The exocrine part of the pancreas produces digestive enzymes, whereas the endocrine part comprises the islet cells which are in charge of synthesis and release of insuline. In the latter part, we mainly focus on immunological topics related to the basic mechanisms of diabetes and autoimmune destruction of the endocrine pancreas. The transformation part addresses the complex cellular and molecular mechanisms which lead to transformation and propagation of pancreatic cancer. In particular, we are interested in understanding changes in gene expression, in particular the identification of novel proto-oncogenes or of novel inactivating mutations in tumour suppressor genes leading to transformation of pancreatic duct cells. Furthermore, we want to identify the molecular mechanisms participating in the transgression from chronic pancreatitis to pancreatic cancer. To achieve these different goals, we have taken a concerted action supported by various groups from basic research as well as clinical medicine.

• DFG Programme: Collaborative Research Centres

Completed projects

• A01 - Induction and control of autoreactive, preproinsulin-specific CD8 T cells in transgene mouse models of typ 1 diabetes (Project Heads Böhm, Bernhard Otto ;  Schirmbeck, Reinhold )
• A3 - Aktivierung autoreaktiver T-Zellen in einem murinen LCMV-GP transgenen Diabetesmodell (Project Head Pechhold, Klaus )
• A04 - Functional Characterization of Autoreactive T Cells in Type 1 Diabetes mellitus (Project Heads Böhm, Bernhard Otto ;  Rosinger, Silke )
• A5 - CCK-induzierte Mechanismen der F-Aktin-Regulation in der Azinuszelle (Project Heads Beil, Michael ;  Lutz, Manfred )
• A6 - Proteaseninduzierte Zytokinaktivierung im Pathomechanismus lokaler und systemischer Komplikationen bei akuter Pakreatitits (Project Head Rau, Bettina )
• A07 - On the role of EMMPRIN and its interaction with pancreatic stellate cells in fibrogenesis und tumor desmoplasia (Project Heads Bachem, Max G. ;  Schneiderhan, Wilhelm )
• A10 - Molecular characterization of acinar-ductal metaplasie in TGF-alpha transgenic mice (Project Head Wagner, Martin )
• A11 - Molekulare Mechanismen und physiologische Bedeutung der G-Proteinabhängigen Regulation von Phosphoinositol-3-Kinasen im exokrinen Pankreas (Project Head Nürnberg, Bernd )
• A12 - Etablierung embryonaler Stammzellinien (ES-Linien) aus NOD (Non Obese Diabetic) Mäusen zum Zwecke des gene targetings im NOD Genom (Project Head Fehling, Hans-Jörg )
• A13 - Molekulare Metamorphose des Epithels im chronisch distendierten Pankreasgang und deren potentielelle Bedeutung in der Initialphase der chronischen Pankreatitis (Project Heads Hasel, Cornelia ;  Möller, Peter )
• A14 - Die Bedeutung der NF-kB Aktivierung für Entstehung und Verlauf der akuten Pankreatitis (Project Heads Weber, Christoph ;  Wirth, Thomas )
• A15 - Regulation of endocrine and neuroendocrine secretion in the pancreas by the protein kinase D family (Project Heads Seufferlein, Thomas ;  Walther, Paul ;  von Wichert, Götz Peter )
• A17 - Molecular analysis of NF-KappaB- induced acute pancreatitis and of the pan creatitis induced fibrosis (Project Heads Baumann, Bernd ;  Wagner, Martin )
• A18 - The role of the RBP-J(kappa) dependent corepressor protein CtIP in pancreatic development and differentiation (Project Head Oswald, Franz )
• A19 - Analyse des Einflusses von Telomerdysfunktion auf die Regeneration und Stammzellfunktion im Pankreas (Project Head Rudolph, Karl Lenhard )
• B01 - Strukturelle und funktionelle Charakterisierung differentiell exprimierter Gene im Pankreaskarzinom mit Hilfe von Kandidatengen-Arrays-/Chips (Project Heads Buchholz, Malte ;  Gress, Thomas Mathias )
• B03 - Identification of the subcellular localization and cellular targets of protein kinase D2, a novel protein kinase overexpressed in pancreatic cancer. (Project Head Seufferlein, Thomas )
• B04 - Molecular and cellular mechanisms organizing the E-cadherin / catenin adhesion complex in pancreatic carcinoma cells. (Project Heads Adler, Guido ;  Menke, Andre )
• B5 - Thymidylat-Stoffwechsel-Marker zur Diagnostik und Therapie-Evaluation des Pankreaskarzinoms mit Positronen-Emissions-Tomographie (PET) (Project Head Reske, Sven Norbert )
• B6 - Einfluß von Smad-4 auf die Tumorgenese im Pankreas (Project Heads Hameister, Horst ;  Schmid, Roland M. )
• B7 - Regulation der gerichteten Migration und Invasion humaner Pankreaskarzinomzellen (Project Heads Giehl, Klaudia ;  Gierschik, Peter )
• B10 - Molekularbiologische Charakterisierung hyperplastischer und dysplastischer Gangepithelveränderungen bei chronischer Pankreatitis und beim Pankreaskarzinom (Project Heads Gansauge, Susanne ;  Mattfeldt, Torsten )
• B12 - Untersuchung zur Expreson und transkriptionellen Regulation von GADD45, einem potentiellen Zielgen von NF-kB in humanen Pankreaskarziomen (Project Head Liptay, Claudia-Susanne )
• B15 - Funktion der Ser/Thr-spezifischen Proteinkinase, Casein Kinase 1 delta in der Tumorigenese des Pankreas (Project Head Knippschild, Uwe )
• B16 - Bedeutung der NFAT-Transkriptionsfaktoren für das phänotypische Verhalten des Pankreaskarzinoms (Project Heads Ellenrieder, Volker ;  Oswald, Franz )
• B17 - Evaluation of IAP antagonists for sensitization of pancreatic cancer to apoptosis (Project Head Fulda, Simone )
• B18 - Effects of FGFR-1-Exonswitching in ductal pancreatic cells (Project Head Kornmann, Marko )
• B19 - Detailed characterization of genomic aberrations in pancreatic cancer and their role in prognosis and therapy (Project Heads Holzmann, Karlheinz ;  Schwänen, Carsten )
• B21 - The influence of the morphological structure of keratin networks for the motility of pancreas carcinoma cells (Project Heads Schmidt, Volker ;  Walther, Paul )
• B22 - Regulation of the viscoelastic properties of the keratin cytoskeleton in pancreatic carcinoma cells (Project Heads Beil, Michael ;  Marti, Othmar )
• B23 - Role of NF-KappaB in pancreatic tumour progression (Project Head Wirth, Thomas )
• C1 - Etablierung des Pankreaskarzinom-Xenograft Modells als zentrale Resource (Project Heads Beger, Hans Günther ;  Gansauge, Frank ;  Gress, Thomas Mathias ;  Jilge, Burghart )
• C03 - Zentrale Aufgaben des Sonderforschungsbereichs (Project Head Adler, Guido )
• C4 - Zentrales Ressource Molekularzytogenetische Diagnostik und DNA-Chips (Project Heads Bentz, Martin ;  Gress, Thomas Mathias )
• C05 - Robust Algorithms for clustering and classification of pancreatic cells and tissues (Project Heads Kestler, Hans A. ;  Palm, Günther )

• Applicant Institution: Universität Ulm
• Participating University: Technische Hochschule Ulm
• Spokesperson: Professor Dr. Guido Adler