SFB 623: Molecular Catalysts: Structure and Functional Design
Biology
Medicine
Final Report Abstract
The principal aim of the Collaborative Research Centre SFB 623 "Molecular Catalysts: Structure and Functional Design" at the University of Heidelberg was a broad and interdisciplinary research programme in catalysis. It comprised the whole spectrum of this key technology for the future, ranging from biocatalysis in living cells to processes relevant to the large scale industrial production of basic chemicals. This type of approach was thought to be essential for the development of chemistry itself, as well as an interfacial science, which drives the technological innovation process in highly industrialized countries. Through a combination of experimental and theoretical methods and expertise within and between the research groups involved, and by exploiting the whole methodological armory of modern molecular chemistry, it has been possible to elucidate the structural basis and mechanistic details of a number of important molecular catalytic systems. One of the key aims of the SFB 623 has been the discovery and development of novel strategies for the identification and investigation of elementary steps and intermediates in catalytic reaction cycles. This subsequently provided the basis fort he improvement and optimization of the activity, selectivity, stability and thus efficiency of known and relevant catalyst systems, as well as the targeted search for new catalytically active molecules. This was supplemented by the investigation of entirely new basis reactions for catalysis based chemistry employing both theoretical and experimental methods and strategies. In several favourable cases this resulted in a rational design and identification of novel molecular catalysts and catalytic reactions, based on mechanistic insight as well as structure function relationships. The obvious relevance of the research project to technical, industrial applications provided an important point of reference, whereas engineering-related aspects remained outside of the main focus of the research programme.
Publications
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Angew. Chem. Int. Ed. 2004, 43, 1283
M. R. Bukowski, P. Comba, C. Limberg, M. Merz, L. Que Jr., T. Wistuba
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Chem. Commun. 2004, 896
C. Welter, O. Koch, G. Lipowsky, G. Helmchen
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J. Am. Chem. Soc. 2005, 127, 15061
M. Jagoda, S. Warzeska, H. Pritzkow, H. Wadepohl, P. Imhof, J. C. Smith, R. Krämer
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J. Am. Chem. Soc. 2005, 127, 9271
R. Fiammengo, K. Musilek, A. Jäschke
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Angew. Chem. Int. Ed. 2006, 45, 3446
M. R. Bukowski, P. Comba, A. Lienke, C. Limberg, C. Lopez de Lorden, R. Mas-Balleste, M. Merz, L. Que Jr.
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Angew. Chem. Int. Ed. 2006, 45, 5546
R. Weihofen, O. Tverskoy, G. Helmchen
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Angew. Chem. Int. Ed. 2006, 45, 5681
J. Bautz, M. R. Bukowski, A. Stubna, M. Kerscher, A. Lienke, P. Comba, E. Münck, L. Que Jr.
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Angew. Chem. Int. Ed. 2007, 46, 3363
A. Kiel, J. Kovacs, A. Mokhir, R. Krämer, D. P. Herten
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Angew. Chem. Int. Ed. 2007, 46, 8067
J. Bautz, P. Comba, C. Lopez de Laorden, M. Menzel, G. Rajaraman
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Proc. Natl. Acad. Sci. USA, 2007, 104, 99
K. Kühnel, E. Deurat, J. Terner, S. Shaik, I. Schlichting
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Angew. Chem. Int. Ed. 2008, 47, 4546
B. Jacques, C. Dro, S. Bellemin-Laponnaz, H. Wadepohl, L. H. Gade
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Angew. Chem. Int. Ed. 2008, 47, 4670
B. K. Langlotz, H. Wadepohl, L. H. Gade
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Angew. Chem. Int. Ed. 2008, 47, 7652
S. Spiess, C. Welter, G. Franck, J.-P. Taquet, G. Helmchen
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Biochemistry 2008, 47, 6552
K. Kühnel, N., Ke, M. Cryle, S. G. Sligar, M. A., Schuler, I. Schlichting
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J. Phys. Chem. A 2008, 112, 13139
R. Xu, M. Bittner, G. Klatt, H. Köppel
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Angew. Chem. Int. Ed. 2009, 48, 1609
N. Schneider, M. Finger, C. Haferkemper, S. Bellemin-Laponnaz, P. Hofmann, L. H. Gade
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Angew. Chem. Int. Ed. 2009, 48, 4417
B. Wucher, M. Moser, S. A. Schumacher, F. Rominger, D. Kunz
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Angew. Chem. Int. Ed. 2009, 48, 4426
P. Fournier, R. Fiammengo, A. Jäschke
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Angew. Chem. Int. Ed. 2009, 48, 8247
A. S. K. Hashmi, A. M. Schuster, F. Rominger
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Chem. Eur. J. 2009, 15, 11515
N. Schneider, M. Finger, C. Haferkemper, S. Bellemin-Laponnaz, P. Hofmann, L. H. Gade
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Angew. Chem. Int. Ed. 2010, 49, 8751
S. Mark, A. Kurek, R. Mülhaupt, R. Xu, G. Klatt, H. Köppel, M. Enders
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Angew. Chem. Int. Ed. 2010, 49, 9270
L. Wang, P. Li, D. Menche
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J. Am. Chem. Soc. 2010, 132, 8846
J. Schoch, M. Wiessler, A. Jäschke
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Angew. Chem. Int. Ed. 2011, 50, 2940
M. Schwering, A. Kiel, A. Kurz, K. Lymperopoulos, A. Sprödefeld, R. Krämer, D.-P. Herten
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Angew. Chem. Int. Ed. 2011, 50, 5757
T. Gehrmann, J. Lloret Fillol, S. Scholl, H. Wadepohl, L. H. Gade
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J. Am. Chem. Soc. 2011, 133, 16444
J. Troendlin, J. Rehbein, M. Hiersemann, O. Trapp
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J. Am. Chem. Soc. 2011, 133, 2072
M. Gärtner, S. Mader, K. Seehafer, G. Helmchen
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Organometallics 2011, 30, 2790
M. E. Tauchert, D. C. M. Warth, S. M. Braun, I. Gruber, A. Ziesak, F. Rominger, P. Hofmann
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Proc. Natl. Acad. Sci. USA, 2011, 108, 7793
S. Kühner, S. Fischer
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Angew. Chem. Int. Ed. 2012, 51, 9425
L. Wang, D. Menche
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Chem. Eur. J. 2012, 14314
J. A. Raskatov, M. Jäkel, B. F. Straub, F. Rominger, G. Helmchen
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Chem. Eur. J. 2012, 18, 3925
T. Gehrmann, S. A. Scholl, J. Lloret Fillol, H. Wadepohl, L. H. Gade
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J. Am. Chem. Soc. 2012, 134, 10769
Q.-H. Deng, H. Wadepohl, L. H. Gade
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J. Am. Chem. Soc. 2012, 134, 2946
Q.-H. Deng, H. Wadepohl, L. H. Gade
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J. Phys. Chem. A 2012, 116, 1077
R. Xu, G. Klatt, M. Enders, H. Köppel
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Angew. Chem. Int. Ed. 2013, 52, 3186
H. Cahova, A. Jäschke
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Angew. Chem. Int. Ed. 2013, 52, 6322
A. Rybina, C. Lang, M. Wirtz, K. Grußmayer, A. Kurz, F. Maier, A. Schmitt, O. Trapp, G. Jung, D.-P. Herten
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Chem. Eur. J. 2013, 19, 3954
G. Klatt, R. Xu, M. Pernpointner, L. Molinari, T. Q. Hung, F. Rominger, A. S. K. Hashmi, H. Köppel
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J. Am. Chem. Soc. 2013, 135, 5356
Q.-H. Deng, T. Bleith, H. Wadepohl, L. H. Gade
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J. Phys. Chem. A 2013, 117, 12635
O. Hübner, H.-J. Himmel
