Autoaggressive CD4+ T cells participate in autoimmune liver disease (A01)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199

The mechanism of action of liver CD4+ T cells in autoimmune liver diseases remains unclear. By combining systems and experimental immunology, along with human samples and mouse experiental models, we aim to identify (i) the antigen specificity, (ii) the epigenetic profile underlying the plastic activation mechanisms and, finally, (iii) to test the in vivo function of liver CD4+ T cells. The long-term goal of this project is to discover molecular mechanisms to reprogram these cells from pathogenic to anti-inflammatory, taking advantage of their potential plasticity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1700: Immune regulation in the liver: from homeostasis to disease
• Applicant Institution: Universität Hamburg
• Project Head: Professor Nicola Gagliani, Ph.D.