Nucleation dynamics in field theories for intracellular phase separation (R17#)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647

Solidification of protein aggregates is a major factor in the development of neurodegenerative diseases, such that understanding it is of high medical relevance. Recent experiments show a multi-stage solidification process in which proteins first form droplets via liquid-liquid phase separation, which then undergo a solidification process promoted by the droplet surface. In this project, we will model this process via a newly developed field theory. On this basis, we will develop passive and active nucleation theories for both liquid-liquid phase separation and protein aggregate solidification.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1551: Polymer Concepts in Cellular Function
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professor Dr. Michael te Vrugt