Biophysical Characterization of Diatom Adhesive Mucilage

• Applicant: Dr. Jens Friedrichs
• Subject Area: Biophysics ; Biomaterials
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 558974393

Adhesion, a fundamental natural process, ranges from gecko climbing mechanisms to the cellular bonds in mammalian tissues. Despite the ecological importance and prevalence of raphid diatoms, research into their adhesive mucilage (AM), crucial for their gliding motility, has been less extensive than in other areas of diatom biology. The proposal, therefore, aims to undertake a detailed analysis of AM, addressing both its natural and purified states. Advanced AFM-based protocols are to be developed for assessing the structural and biophysical properties of hydrated, naturally deposited AM. The study will also extend to the biophysical and adhesive traits of purified AM across various surface energies. It is hypothesized that the proteins within AM are organized into complex hierarchical structures, essential for adhesion. Moreover, the interaction between AM and different surfaces is believed to influence its adhesive and mechanical properties. Research into diatom AM is poised to have a profound impact on various scientific and engineering sectors, potentially enriching the understanding of natural adhesion and guiding the development of new antifouling surfaces and underwater adhesives.

• DFG Programme: Research Grants