Project Details
Projekt
Dissecting cell fate regulation in USSC
Applicant
Professor Dr. Peter Wernet
Subject Area
Hematology, Oncology
Term
from 2007 to 2011
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 20803802
According to their pluripotent developmental capacity unrestricted somatic stem cells (USSC)are an intriguing system to analyze mechanisms defining pluripotency or regulating themaintenance, the specification and realization of different cell fates, respectively. Thescientific aim of our group is to obtain gene expression and microRNA signatures of USSCand their derivatives and to compare them with corresponding signatures of human embryonicstem cell lines. At the basis of these signatures we like to identify transcription factors as wellas microRNAs, which are functionally associated with the pluripotent state of USSC andothers, which are functionally involved in controlling the decision process of self-renewalversus differentiation of USSC. By over-expression as well as by loss of function experimentswe will analyze the impact of identified candidates on these processes and aim to define anepistatic cascade of factors governing self-renewal, pluripotency, and distinct lineagecommitment of USSC.
DFG Programme
Research Units
Participating Persons
Professor Dr. Bernd Giebel; Dr. Hans-Ingo Trompeter
