Project Details
Projekt
Fast oscillatory control of spike timing-dependent synaptic plasticity (STDP) in the rodent hippocampus
Subject Area
Experimental and Theoretical Network Neuroscience
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 560307581
The mammalian hippocampus has two prominent features: spike timing-dependent synaptic plasticity (STDP) and state-dependent network oscillations. Both functions require precise timing of spikes and synaptic potentials, suggesting that they are closely related and interdependent. However, this interaction has gained little attention so far. We want to study systematically how oscillating activity patterns affect the relative timing of synaptic potentials and action potentials, how different oscillatory states affect spike timing-dependent synaptic plasticity, and how the interaction between STDP and network oscillations affects the generation or stability of memory-related neuronal ensembles. Our model system is the mouse hippocampus, where we will focus on cell- and network-level activity in the CA1 region. Our approach comprises high-resolution electrophysiological recordings, closed-loop interventions into oscillating networks, and extensive use of computer modelling to generate hypotheses which can be experimentally tested. We will join forces between laboratories with background in network oscillations (Draguhn), spike timing-dependent synaptic plasticity (Lessmann) and, in close cooperation, a group with strong expertise in computer modelling (Migliore). We hope to make significant contributions to the fundamental question how timing of activity contributes to the formation of network patterns and functional neuronal ensembles.
DFG Programme
Research Grants
International Connection
Israel, Italy
Cooperation Partners
Professor Dr. Ilya Fleidervish; Professor Dr. Michele Migliore
