Raman spectroscope with different probes

• Subject Area: Process Engineering, Technical Chemistry
• Term: Funded in 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 562411438

A Raman spectroscope with different probes for the structural analysis of a wide range of materials and measurement tasks is to be purchased at the PharmaCampus of the University of Münster. The mobile measurement device, equipped with different types of probes, enables flexible, interdisciplinary use directly in processes or in analytical measurement set-ups. The Raman spectroscope will not only be used for pharmaceutical research questions, but also in a chemical-process engineering context for structural analysis in the preparation of battery electrodes. While Raman microscopes cannot be used without sample preparation due to their rigid design, the Raman spectroscope enables flexible and location-independent use. The liquid and contactless probes will contribute to a deeper understanding of a wide range of processes and (intermediate) products with the possibility of carrying out an analysis directly inline. The liquid probes are used for the analysis of liquid or semi-solid formulations. Changes in (nanoparticulate) samples can be observed inline over storage periods or during reaction processes and spectra are recorded at defined time intervals. Furthermore, liquid starting materials, intermediate and final products are also to be analyzed offline. Focused contactless probes, on the other hand, are used to analyze powders and solid containing active ingredients or dosage forms such as tablets or orodispersible films. These probes also make it possible to record spectra of different types through transparent vessel walls. This measurement set-up is used when sampling is not possible without problems, for example because living organisms such as cells can be damaged, or system equilibria can be disturbed. Non-focused contactless probes are used for the analysis of samples when larger sample areas or highly disperse systems are to be analyzed. The non-contact probes are installed in nebulizing processes such as spray drying. The data collected is then fed into numerical simulations, which help to understand the underlying flow patterns and temperature exposures on the product during the process.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Raman-Spektroskop mit verschiedenen Sonden
• Instrumentation Group: 1840 Raman-Spektrometer
• Applicant Institution: Universität Münster
• Leader: Professorin Dr.-Ing. Denise Steiner