Deciphering plasticity of relapse-driving, chemo-resistant LSC states in DNMT3Amut NPM1mut AML (A05)

• Subject Area: Hematology, Oncology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

In project A05 single cell multi-omics will be applied to analyze triplet primary AML samples (diagnosis, remission, relapse) to identify reversible plastic LSC states and identify non-genetic molecular drivers of dormancy and thus resistance and relapse. Furthermore, A05 will elaborate metabolic LSC states along the AML therapy course using advanced cellular barcoding technologies to trace plasticity of distinct LSC states.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Andreas Trumpp, Ph.D.