Single cell multi-omics to unravel niche plasticity in AML therapy resistance (B07)

• Subject Area: Hematology, Oncology ; Medical Informatics and Medical Bioinformatics
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

Project B07 will apply single-cell and imaging technologies to characterize BM niche plasticity in AML during the course of the disease and treatment. Identified candidate genes will be functionally investigated by treating AML blasts with niche-targeting drugs acting against niche-induced LSC plasticity. These niche remodeling drugs will be subsequently combined with LSC- targeting drugs and their synergism will be assessed in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Caroline Pabst; Judith Zaugg, Ph.D.