Spatial and epigenetic plasticity during leukemia development and targeted therapeutic intervention (B08)

• Subject Area: Hematology, Oncology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

Project B08 will unravel the spatial and epigenetic plasticity during leukemia development and targeted therapeutic intervention by using a pre-leukemic Npm1c knock-in mouse model, single cell multiomics approaches and spatial profiling of the bone marrow microenvironment. B08 will characterize the pre-leukemic niche of L-HSC clones resistant to epigenetic therapy, and the underlying mechanisms that support resistance to targeted epigenetic therapies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Konstantinos Kokkaliaris, Ph.D.; Hannah Uckelmann, Ph.D.