Inflammation driven plasticity in disease progression in Advanced Systemic Mastocytosis (B09)

• Subject Area: Hematology, Oncology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

By using AdvSM patient samples at different stages of the disease (pre-treatment, remission, primary resistance, and relapse/ secondary resistance) project B09 will characterize the inflammatory cytokine landscape and immune cell composition and dynamically map the inflammatory microenvironment. Using established mouse models of AdvSM disease progression in the absence or presence of induced inflammation using different pro-inflammatory cytokines will be analyzed and compared to patients` data. Multi-omic analysis will identify changes induced by differences in pro-inflammatory cytokine levels that impact on disease progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Marieke Essers; Professor Dr. Andreas Reiter