Clinically annotated primary tumor cells and mouse clinics for patient-derived xenograft (PDX) models (Z02)

• Subject Area: Hematology, Oncology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

Within project Z02 all PIs of the CRC will be provided with (1) shared primary myeloid malignancy samples from the Heidelberg Cell and Liquid Biobank and (2) PDX mouse models for preclinical in vivo treatment assays. We are going to set up a dedicated Mouse Leukemia Clinic for analysis and treatment of PDX models. This mouse clinic will foster collaboration, accelerate research due to standardized procedures and will allow comparisons of diseases and treatment across individual projects. At the same time, the professional team will use all possible 3R criteria to reduce, refine and replace mouse experiments.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Irmela Jeremias; Dr. Nadine Volk