Regulation of metabolic injury in MASLD through interplay of diet and microbiota (A04)

• Subject Area: Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 535081457

To understand MASLD pathomechanisms translatable to prevention, we use high-throughput multi-omics systems biology to investigate their shifts under a randomized controlled trial for an isocaloric dietary intervention in MASLD. In so doing we particularly seek to characterize scope and nature of gut microbiome mediation and modulation of lifestyle risk factors, testing resulting causal hypotheses through microbiome transfer into gnotobiotic mouse models. By exploring the wider scope of cross-systems microbiome, metabolome and phenome correlations, we will further assess likelihood of comorbidity, potential druggability, and sex/gender differentiality of MASLD risk manifestation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 412: Metabolic dysfunction-associated steatotic liver disease: Translating mechanisms to tailored therapeutic concepts
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Sofia K. Forslund-Startceva; Professor Dr. Knut Mai