Molecular, spatial, and cellular mechanisms of necro-inflammation-induced metabolic reprogramming in MASH (A07)

• Subject Area: Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 535081457

Continuous lipid overload in the liver results in a state of chronic necro-inflammation which drives the metabolic reprogramming of hepatocytes in metabolic dysfunction-associated steatohepatitis (MASH). Using a spectrum of omic-technologies including single-cell spatial metabolomics, transcriptomics and multi-parameter imaging, in appropriate models for mouse and human MASH in vitro, ex vivo as well asin vivo, project A07 aims to elucidate the underlying signaling pathways and molecular mechanisms, e.g. the role of PPAR signaling and epigenetic modifications. Complementary function studies will elucidate how these pathways can be manipulated to treat metabolic syndrome-related MASH.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 412: Metabolic dysfunction-associated steatotic liver disease: Translating mechanisms to tailored therapeutic concepts
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professor Dr. Mathias Heikenwälder