Role of microbial amino acid metabolism on chemotherapy response in CRC (P11)

• Subject Area: Immunology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Cell Biology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

Plasticity of microbial ecosystem comprised of complex community of bacteria, fungi, archaea and viruses in gut, plays a decisive role in determining health and has been implicated in CRC or resistance to therapy. The project addresses the critical link between diet, microbiome and cancer with a specific focus on amino acid metabolism. This project aims to examine potential applications of microbiome in precision medicine by targeting microbial tryptophan-indole metabolism employing precision nutrition and innovative in vitro and in vivo tools to enhance anti-tumor immunity and treatment efficacy.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Privatdozentin Melek Canan Arkan, Ph.D.; Dr. Zuzana Tatarova