Identification of immunomodulatory microbial metabolites as novel therapeutics for advanced CRC (P12)

• Subject Area: Gastroenterology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Cell Biology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

The composition of the microbiome has been documented to be very different in mice kept under SPF conditions and animals with microbes from wild mice (so-called wildlings) leading to distinct immune responses and disease outcome. The project hypothesizes that in contrast to SPF-housed mice wildling microbiota will protect from CRC development and aims therefore to systematically compare the impact of such different microbiota on tumor progression and development of metastasis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Stephan Patrick Rosshart