Modulation of CRC development and progressi- on by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota (P13)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

Impaired T cell recruitment into intestinal tumors represents one of the greatest problems for successful immune therapy. P13 examines whether activation of the G protein coupled receptor GPR15 expressed on T cells which are homing to the large intestine may represent a novel strategy for CRC therapy. Expression of GPR15L, the GPR15 ligand, is reduced both in murine and human CRC. Intriguingly, GPR15L does not only act on T cells but also modulates the intestinal microbiome and suppresses directly tumor cell proliferation and represents therefore a very attractive molecule that could shape a tumor suppressive TME.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Dr. Tanja Müller; Professor Dr. Sebastian Zundler