Harmonizing Research: Zwicker Tones and Computational Modelling for Advanced Tinnitus Understanding

• Applicants: Privatdozent Dr. Patrick Krauss; Privatdozent Dr. Achim Schilling
• Subject Area: Human Cognitive and Systems Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 563909707

The proposed research project aims to advance our understanding of auditory perception, specifically focusing on the neural mechanisms underlying Zwicker tone perception and its contrast with normal auditory processing and pathological tinnitus. Spanning 36 months, the project integrates advanced EEG data analysis, machine learning techniques, and computational modeling to explore auditory processing and phantom perceptions in the brain. Key objectives include elucidating the neural underpinnings of Zwicker tones and differentiating them from standard auditory processing and tinnitus. We plan to use deep neural networks as model systems for brain function and compare their internal dynamics with neuroimaging data, a method proven successful in visual processing research. The project's novelty lies in adapting these techniques to tinnitus research. The research plan involves recording EEG responses to auditory stimuli, particularly excitatory ERP offset responses induced by notched tones, and contrasting these with responses to pure tones. This will help understand the nuances of auditory processing and phantom perception. We will also use Representational Similarity Analysis (RSA) to link empirical EEG data with computational model predictions. The project is divided into two main work programs: Data Acquisition and Analysis, and Computational Modelling and Method Development. These include developing stimulus protocols, recruiting participants, conducting EEG measurements, and evaluating ERPs. They will also create and refine neural network models of the auditory pathway, analyze EEG data from healthy participants and tinnitus patients, and compare these findings with model data. The ultimate goal is to enhance understanding of auditory perception, potentially leading to innovative therapeutic strategies and new diagnostic approaches for tinnitus and related auditory conditions. This ambitious project aims to bridge computational neuroscience with experimental auditory neuroscience, offering significant contributions to the field of tinnitus research.

• DFG Programme: Research Grants