Targeting colorectal liver metastasis by overcoming MYC induced immune evasion (P19)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

Nearly all MSS CRCs have an APC mutation, which leads to the overexpression of the MYC proto-oncogene. MYC promotes tumor growth and facilitates immune evasion, ultimately contributing to resistance against immunotherapy, yet MYC also impacts proliferation and function of T and B lymphocytes, making these processes dependent on MYC. P19 will explore whether selectively reducing MYC in colorectal liver metastases (CRLM) makes them detectable by the immune system, which TME-cells exhibit an immune-mediated response while dissecting the effect of MYC in tumor vs. immune cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Armin Wiegering