Project Details
Projekt
Mechanisms of circadian vaccination responses in humans and mice (A01)
Subject Area
Immunology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 541063275
Infectiologist and vaccine researcher Leif Erik Sander and chrono-immunologist Christoph Scheiermann investigate the mechanisms underlying the diurnal variation in vaccine efficacy. Despite the long time course of adaptive immune functions, the initial timing of a vaccine stimulus can have lasting effects on the immune response. However, the underlying mechanisms are difficult to understand because vaccine "depots" are present in tissues as a source of antigen and provide immune stimulation for several days. This project will combine mechanistic studies in mouse models and human biospecimens with retrospective and prospective time-of-day studies in human clinical vaccination cohorts to provide the mechanistic basis for an informed choice of optimal vaccination timing.
DFG Programme
CRC/Transregios
Subproject of
TRR 418:
Foundations of Circadian Medicine
International Connection
Switzerland
Applicant Institution
shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
Charité - Universitätsmedizin Berlin
