Project Details
Projekt
Coordination Funds
Applicant
Professor Dr. Matthias Ebert
Subject Area
Gastroenterology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 537604907
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second leading cause of cancer-related deaths worldwide. Genomic-based precision medicine has raised hopes of improved cancer survival rates by tailoring the treatment to the specific molecular alterations underlying this and other cancers. However, in translational trials using large-scale genomic sequencing, personalised treatments were identified for less than 20% of patients. This limited success highlights the need to integrate the complex, dynamic and heterogeneous genotypes and phenotypes of the cancer ecosystem. This ecosystem includes the recently described microbiota-gene-drug interface, which now opens new opportunities to target CRC. Through 8 scientific and 2 central projects, implemented by a highly gender-balanced group of PIs (including 6 junior PIs) that bring together the required wide array of expertise, the GenoMiCC research unit will address functional genomics and microbiomics in CRC, in order to identify new druggable and accessible targets for personalised therapy. Together, our team of basic and clinician scientists will extend existing cooperations to transfer novel findings into next generation precision medicine-based clinical trials.
DFG Programme
Research Units
