Electrically stimulated 3D Scaffold for Bone Regeneration

• Applicant: Dr. Amir Fahmi
• Subject Area: Biomaterials ; Synthesis and Properties of Functional Materials ; Medical Physics, Biomedical Technology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 570110040

The design, fabrication, and characterization of three-dimensional (3D) structured hybrid nanofibers mimicking the tissue matrix have great potential for tissue regeneration applications. Applying external electrical stimulation on scaffolds for bone tissue engineering enables the regeneration of bone tissues comprising native hierarchically organized extracellular matrix (ECM) and multiple tissue interfaces. Bone regeneration engineering emerges as a transformative field, and it is particularly crucial in cases of traumatic injuries, fractures, and/or orthopedic surgeries, where traditional methods prove inadequate. RESBONREG aims to design and fabricate 3D construct hybrid nanostructured biomaterials that mimic the structural and functional characteristics of bone tissues. Controlled electrical stimulation (ES) will be employed to promote cell proliferation, differentiation, migration, adhesion, and the secretion of growth factors. Finite element model (FEM) simulations will be utilized to evaluate the effect of scaffold presence on alteration of local electric field patterns. The ES accelerates the maturation of bone tissue and contributes to improving mechanical strength by controlling the synergistic effect between the native bone tissue and the engineered scaffolds to induce bioactive compounds. These elements are vital to accelerate the bone healing process.

• DFG Programme: Research Grants
• International Connection: Austria, Czech Republic
• Partner Organisation: Czech Science Foundation; Fonds zur Förderung der wissenschaftlichen Forschung (FWF)
• Cooperation Partners: Privatdozentin Dr. Eva Filová; Privatdozentin Dr. Theresa Rienmüller