Nanoparticles: Synthesis, characterisation, and cellular effects

• Antragsteller: Professor Dr.-Ing. Henning Bockhorn; Dr. Hanns-Rudolf Paur; Dr. Harald Saathoff; Privatdozent Dr. Carsten Weiss
• Fachliche Zuordnung: Technische Chemie ; Pharmakologie ; Physikalische Chemie von Molekülen, Flüssigkeiten und Grenzflächen, Biophysikalische Chemie
• Förderung: Förderung von 2008 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 57095923

The aim of the project is to quantify the influence of the properties of metal-oxide nanoparticles (size, degree of agglomeration, chemical composition, surface properties, and coating) on the induction of cellular signalling pathways which are characteristic for the response to oxidative stress and immune reactions. Within the framework of the project proposed, nanoparticles with defined composition, size distribution, and surface properties will be synthesised, transferred into an aerosol with defined size/morphology, and deposited on lung cells via the air/liquid interface with well defined mass, number, and surface doses. Ultimately, the biological responses in cell systems will be quantified, the nanoparticles will be localised in the cellular compartments and the underlying mechanisms of action will be analysed.

• DFG-Verfahren: Schwerpunktprogramme
• Teilprojekt zu: SPP 1313: Biological Responses to Nanoscale Particles (Bio-Nano-Responses)
• Beteiligte Person: Dr. Silvia Diabaté