Data-driven mapping of prebiotic phosphate activation (A12#)

• Subject Area: Physical Chemistry of Molecules, Liquids and Interfaces, Biophysical Chemistry
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 521256690

Organic phosphates are crucial in biochemistry, forming the backbone of the genetic molecules RNA/DNA and facilitating energy metabolism, yet the activation and transfer of inorganic phosphate in water remains a fundamental challenge within prebiotic chemistry. In this project, we will identify the constraints that enable some electrophilic organic molecules to selectively activate inorganic phosphate in water. Based on experimental kinetic studies and quantum chemical calculations, we will train regression models and establish quantitative structure-reactivity relationships. Together with CRC collaborators, we will then apply our methodology to known and newly identified systems under different environmental constraints and geochemical settings.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 392: Molecular evolution in prebiotic environments
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Robert Mayer