Epigenetic mechanisms in the physiological development and malignant transformation of primordial germ cells (A01)

• Subject Area: Reproductive Medicine, Urology ; Cell Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 549467913

Mismigration and accompanying transformation of primordial germ cells during embryo development can lead to infertility and rhabdoid tumours. These tumours are associated with mutations in the SMARCB1 gene, resulting in epigenetic dysregulation. This project gains insights into the genetic mechanisms underlying the transformation of germ cells. Using comprehensive gene-knockout analyses in in vitro models, the relevance of particular genes for the function of germ-cell development will be assessed. This will shed light on the pathomechanisms of male infertility and may be translated into treatment strategies for children with rhabdoid tumours.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1748: Principles of Reproduction – Unravelling the Molecular Mechanisms of Male Infertility
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Kornelius Kerl